Coward, William R. and Feghali-Bostwick, Carol A. and Jenkins, Gisli and Knox, Alan J. and Pang, Linhua (2014) A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary

Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis.

Diminished cyclooxygenase 2 (COX-2) expression in fibroblasts, with a resultant defect in the production of the antifibrotic mediator prostaglandin E(2), plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Here, we have characterized the molecular mechanism. We found that COX-2 mRNA levels in fibroblasts from patients with IPF (F-IPF) were significantly lower than those...

Proliferator-Activated Receptors Smooth Muscle Cells: Role of Peroxisome Anti-inflammatory Drugs in Human Airway Cyclooxygenase-2 Expression by Nonsteroidal

Cells: Role of Cyclooxygenase Products Cultured Human Airway Smooth Muscle Bradykinin Stimulates IL-8 Production in

Transcriptional Regulation of Cyclooxygenase 2 by Bradykinin and Interleukin-1 in Human Airway Smooth Muscle Cells: Involvement of Different Promoter Elements, Transcription Factors, and Histone H4 Acetylation

The K+ Channel KCa3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a common, progressive and invariably lethal interstitial lung disease with no effective therapy. We hypothesised that K(Ca)3.1 K(+) channel-dependent cell processes contribute to IPF pathophysiology. METHODS K(Ca)3.1 expression in primary human lung myofibroblasts was examined using RT-PCR, western blot, immunofluorescence and patch-clamp elec...